التفاصيل البيبلوغرافية
| العنوان: |
Internal Responsiveness of EQ-5D-5L and EORTC QLQ-C30 in Dutch Breast Cancer Patients during the First Year Post-Surgery: A Longitudinal Cohort Study. |
| المؤلفون: |
Vrancken Peeters, Noëlle J. M. C., van Til, Janine A., Huberts, Anouk S., Siesling, Sabine, Husson, Olga, Koppert, Linetta B. |
| المصدر: |
Cancers; Jun2024, Vol. 16 Issue 11, p1952, 15p |
| مصطلحات موضوعية: |
PREOPERATIVE period, HEALTH status indicators, RESEARCH funding, BREAST tumors, QUESTIONNAIRES, LIFE expectancy, VISUAL analog scale, CANCER patients, DESCRIPTIVE statistics, MANN Whitney U Test, LONGITUDINAL method, QUALITY of life, HEALTH outcome assessment, POSTOPERATIVE period |
| مستخلص: |
Simple Summary: Breast cancer is one of the most diagnosed malignancies among women worldwide, affecting 18,000 women annually in the Netherlands. As life expectancy increases, monitoring quality of life (QoL) using Patient-Reported Outcome Measures (PROMs) becomes more important. The EQ-5D-5L and the EORTC QLQ-C30 are two widely used PROMs in the Netherlands. For utilizing PROMs in research and clinical care, internal responsiveness is key. Given the broad application of these PROMs in the Netherlands and the fact that internal responsiveness varies based on the disease, treatment regime, and geographical factors, this study assesses and compares the internal responsiveness of the EQ-5D-5L and the EORTC QLQ-C30 among Dutch breast cancer patients during the first year post-surgery. The results demonstrated that the EQ-5D-5L and the EORTC QLQ-C30 have small internal responsiveness (<0.5) at 6- and 12 months post-surgery. These findings provide crucial insights for interpreting outcomes from both PROMs in research and clinical practice. The EuroQoL 5-Dimension 5-Level questionnaire (EQ-5D-5L) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30) are commonly used Patient-Reported Outcome Measures (PROMs) for breast cancer. This study assesses and compares the internal responsiveness of the EQ-5D-5L and EORTC QLQ-C30 in Dutch breast cancer patients during the first year post-surgery. Women diagnosed with breast cancer who completed the EQ-5D-5L and EORTC QLQ-C30 pre-operatively (T0), 6 months (T6), and 12 months post-surgery (T12) were included. Mean differences of the EQ-5D-5L and EORTC QLQ-C30 between baseline and 6 months (delta 1) and between baseline and 12 months post-surgery (delta 2) were calculated and compared against the respective minimal clinically important differences (MCIDs) of 0.08 and 5. Internal responsiveness was assessed using effect sizes (ES) and standardized response means (SRM) for both deltas. In total, 333 breast cancer patients were included. Delta 1 and delta 2 for the EQ-5D-5L index and most scales of the EORTC QLQ-C30 were below the MCID. The internal responsiveness for both PROMs was small (ES and SRM < 0.5), with greater internal responsiveness for delta 1 compared to delta 2. The EQ-5D-5L index showed greater internal responsiveness than the EORTC QLQ-C30 Global Quality of Life scale and summary score. These findings are valuable for the interpretation of both PROMs in Dutch breast cancer research and clinical care. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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