التفاصيل البيبلوغرافية
العنوان: |
Antihyperlipidemic activity of myricetin. |
المؤلفون: |
Yang, Z.Z., Zhang, J.Q., Shi, B.B., Qian, J.Q., Guo, H. |
المصدر: |
Acta Alimentaria; Jun2024, Vol. 53 Issue 2, p292-304, 13p |
مصطلحات موضوعية: |
FATTY acid synthases, MYRICETIN, PEROXISOME proliferator-activated receptors, DIETARY supplements, GENE expression |
مستخلص: |
Myricetin has been reported to have a wide variety of beneficial physiological functions. The present study investigated the antihyperlipidaemic activity of myricetin against hyperlipidaemia of high-fat diet-fed obese rats. The four-week antihyperlipidaemic activity was assayed by giving different doses of myricetin to hyperlipidaemic rats. Results showed that myricetin could reduce the harm caused by oxidative stress, decrease thiobarbituric acid reactive substances value, and decrease total cholesterol and triacylglycerol levels of hyperlipidaemic rats. Quantitative analysis of gene expression showed that myricetin's lipid-lowering activity can be activated by downregulating gene expression of fatty acid synthase (FAS) and peroxisome proliferator-activated receptor-γ (PPARγ) with upregulation of hormone-sensitive lipase (HSL) mRNA level. Thus, myricetin had significant health benefits and could be explored as a potentially promising dietary supplement for treating hyperlipidaemia. [ABSTRACT FROM AUTHOR] |
|
Copyright of Acta Alimentaria is the property of Akademiai Kiado and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
قاعدة البيانات: |
Complementary Index |