التفاصيل البيبلوغرافية
| العنوان: |
Genetic Association Between Polycystic Ovary Syndrome and the APOA5 rs662799 and PLIN1 rs894160 Metabolic Variants in the Western Saudi Population: A Case-Control Study. |
| المؤلفون: |
Bakhashab, Sherin, Batarfi, Asma A, Alhartani, Mahinar M, Turki, Rola, Mady, Wessam |
| المصدر: |
Biomarker Insights; 6/16/2024, p1-9, 9p |
| مصطلحات موضوعية: |
POLYCYSTIC ovary syndrome, SINGLE nucleotide polymorphisms, INDUCED ovulation, SAUDI Arabians, CHILDBEARING age, CASE-control method |
| مستخلص: |
Background: Polycystic ovary syndrome (PCOS) is a common endocrinological condition affecting women of reproductive age, associated with insulin resistance and obesity. PCOS pathogenesis is complex and multifactorial, involving genetic and environmental factors. Objectives: This study aimed to determine and compare genotype and allele frequencies of single nucleotide polymorphisms (SNPs) in the apolipoprotein A5 (APOA5 ; rs662799) and perilipin 1 (PLIN1 ; rs894160, rs1052700 and rs6496589) genes in Western Saudi women to investigate their association with PCOS and its clinical characteristics. Design and methods: This was a case-control study conducted on women with (n = 104) and without (n = 87) PCOS. The SNPs were genotyped using TaqMan genotyping assays. Results: Significant and direct associations were detected between PCOS susceptibility and APOA5 SNP rs662799 and PLIN1 SNP rs894160 (P <.001). For APOA5 SNP rs662799, women with the A allele were more likely to have PCOS (relative risk [RR] = 1.348, odds ratio [OR] = 2.313, P <.001) and hypertriglyceridaemia (OR = 17.0, P =.5) than women with the G allele. For PLIN1 SNP rs894160, women with the T allele were more likely to have PCOS than women with the C allele (RR = 8.043, OR = 7.427, P <.001). For PLIN1 SNP rs1052700, women with the TT genotype were more likely to have hyperandrogenism (OR = 29.75, P =.02) and an irregular period (OR = 0.07, P =.040) than women with the AT genotype. Conclusion: We identified novel alleles and genotypes contributing to the genetic risk of PCOS in the Western Saudi population. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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