التفاصيل البيبلوغرافية
| العنوان: |
Abnormal phosphorylation / dephosphorylation and Ca2+ dysfunction in heart failure. |
| المؤلفون: |
Liu, Yan-Bing, Wang, Qian, Song, Yu-Ling, Song, Xiao-Min, Fan, Yu-Chen, Kong, Lin, Zhang, Jing-Sai, Li, Sheng, Lv, Yi-Ju, Li, Ze-Yang, Dai, Jing-Yu, Qiu, Zhen-Kang |
| المصدر: |
Heart Failure Reviews; Jul2024, Vol. 29 Issue 4, p751-768, 18p |
| مصطلحات موضوعية: |
DEPHOSPHORYLATION, HEART failure, PHOSPHORYLATION, CALCIUM channels, HEART beat |
| مستخلص: |
Heart failure (HF) can be caused by a variety of causes characterized by abnormal myocardial systole and diastole. Ca2+ current through the L-type calcium channel (LTCC) on the membrane is the initial trigger signal for a cardiac cycle. Declined systole and diastole in HF are associated with dysfunction of myocardial Ca2+ function. This disorder can be correlated with unbalanced levels of phosphorylation / dephosphorylation of LTCC, endoplasmic reticulum (ER), and myofilament. Kinase and phosphatase activity changes along with HF progress, resulting in phased changes in the degree of phosphorylation / dephosphorylation. It is important to realize the phosphorylation / dephosphorylation differences between a normal and a failing heart. This review focuses on phosphorylation / dephosphorylation changes in the progression of HF and summarizes the effects of phosphorylation / dephosphorylation of LTCC, ER function, and myofilament function in normal conditions and HF based on previous experiments and clinical research. Also, we summarize current therapeutic methods based on abnormal phosphorylation / dephosphorylation and clarify potential therapeutic directions. [ABSTRACT FROM AUTHOR] |
|
Copyright of Heart Failure Reviews is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder