التفاصيل البيبلوغرافية
| العنوان: |
Paleo-Siberian Substrate in the Gene Pool of Koryaks according to Data on Autosomal SNP Polymorphism and Y-Chromosome Haplogroups. |
| المؤلفون: |
Kharkov, V. N., Kolesnikov, N. A., Zarubin, A. A., Valikhova, L. V., Khitrinskaya, I. Yu., Voevoda, M. I., Gubina, M. A., Sukhomyasova, A. L., Stepanov, V. A. |
| المصدر: |
Russian Journal of Genetics; Jun2024, Vol. 60 Issue 6, p787-796, 10p |
| مصطلحات موضوعية: |
HAPLOGROUPS, Y chromosome, GENETIC polymorphisms, INBREEDING, SINGLE nucleotide polymorphisms, HAPLOTYPES |
| مستخلص: |
The gene pool of the Koryaks was studied in comparison with other Far Eastern and Siberian peoples using a genome-wide panel of autosomal single-nucleotide polymorphic markers and Y-chromosome markers. The results of analyzing the frequencies of autosomal SNPs using various methods, the similarity in the composition of Y-chromosome haplogroups and YSTR haplotypes indicate that the gene pool of the Koryaks is as close as possible to the Chukchi one and was formed as a result of the unification of several groups whose ancestors had moved from the territory of modern Yakutia and the Amur region. The two dominant Y-chromosome haplogroups of the Koryaks with different sublines of haplotype clusters demonstrate their contacts with the Chukchi, Evens, Yukaghirs, and Eskimos. Analysis of the composition of genetic components and IBD blocks on autosomes indicates the maximum genetic proximity of the Koryaks to the Chukchi. Among the Siberian populations, the Chukchi, Koryaks, and Nivkhs form a cluster separate from the main group of Siberian populations, while the Chukchi and Koryaks are more closely related. Far Eastern populations are divided in full accordance with geographic localization into the northern group (Chukchi and Koryaks) and the southern group, including the Nivkhs and Udege. A more detailed analysis of the component composition of gene pools in some populations reveals components specific to them. The isolation of such components is associated with founder effects and a shift in allele frequencies for these populations. The Koryaks and Chukchi represent one of the most striking examples of long-standing genetic kinship. Their populations demonstrate maximum values of the level of genomic inbreeding FROH > 1.5 (0.0422, 0.0409), which is natural due to their relative isolation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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