التفاصيل البيبلوغرافية
| العنوان: |
Exchange transfusion combined with artesunate (ET-AS) as a safe and effective therapy in severe P. falciparum malaria: a case series. |
| المؤلفون: |
Zhang, Jingjing, Chen, Lulu, Zhang, Min, Yao, Mingkang, Ren, Saisai, Liu, Haihui, Min, Yanan, Jia, Yan, Tao, Yanling, Zhang, Hao |
| المصدر: |
BMC Infectious Diseases; 6/19/2024, Vol. 24 Issue 1, p1-6, 6p |
| مصطلحات موضوعية: |
BLOOD transfusion, MALARIA, CEREBRAL malaria, INTENSIVE care units, PLASMA products |
| مستخلص: |
Background: the mortality associated with severe malaria due to Plasmodiun falciparum remains high despite improvements in malaria management. Case prensentation: this case series aims to describe the efficacy and safety of the exchange transfusion combined with artesunate (ET-AS) regimen in severe P. falciparum malaria. Eight patients diagnosed with severe P. falciparum malaria were included. All patients underwent ET using the COBE Spectra system. The aimed for a post-exchange hematocrit of 30%. Half the estimated blood volume was removed and replaced using fresh frozen plasma. The regimen was well-tolerated without complications. The parasite clearance time ranged from 1 ~ 5 days. Five patients with cerebral malaria exhibited full improved consciousness within 3 days, while patient2 with hemolysis improved on day 2. Liver function improved within 1 ~ 6 days, and patient 1 and patient 6 showed improvements renal function on days 18 and 19, respectively. The length of intensive care unit stay range from 2 ~ 10 days, and all patients treated with ET-AS remained in the hospital for 3 ~ 19 days. Conclusions: these preliminary results suggest that ET-AS regimens are a safe and effective therapy for severe P. falciparum malaria and can benefit patients in clinical settings. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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