التفاصيل البيبلوغرافية
| العنوان: |
DETERMINATION OF DNA DAMAGE INDUCED BY BISPHENOL A AND BISPHENOL S IN MCF7 CELL LINE. |
| Alternate Title: |
BİSFENOL A VE BİSFENOL S'NİN MCF7 HÜCRE HATTINDA NEDEN OLDUĞU DNA HASARININ ARAŞTIRILMASI. (Turkish) |
| المؤلفون: |
ERDOGMUS, Ekin, IPEK TEKNECI, Seda, KOCER GUMUSEL, Belma, DUYDU, Yalcin, USTUNDAG, Aylin |
| المصدر: |
Journal of Faculty of Pharmacy of Ankara University / Ankara Üniversitesi Eczacilik Fakültesi Dergisi; 2024, Vol. 48 Issue 2, p552-558, 7p |
| مصطلحات موضوعية: |
DNA damage, BISPHENOL A, CELL lines, BREAST cancer, POLYMERIZATION |
| Abstract (English): |
Objective: This study aimed to determine the DNA damage induced by Bisphenol A (BPA) and Bisphenol S (BPS) on MCF7 cell line. Material and Method: DNA damage was determined by COMET assay in MCF7 cell line at 0.1, 0.5, 1, 5, 10 and 50 µM concentrations of BPA and BPS. Result and Discussion: All BPA and BPS concentrations studied (0.1, 0.5, 1, 5, 10 and 50 µM) significantly induced DNA damage on MCF7 cell line compared with control (p<0.05). BPS significantly induced DNA damage more than BPA at the 3 highest concentrations studied (5, 10 and 50 µM) (p<0.05). This study shows that bisphenol derivatives can also cause DNA damage like BPA. [ABSTRACT FROM AUTHOR] |
| Abstract (Turkish): |
Amaç: Bu çalışmada, Bisfenol A (BPA) ve Bisfenol S (BPS)'nin MCF7 hücre hattında neden olduğu DNA hasarının belirlenmesi amaçlanmıştır. Gereç ve Yöntem: DNA hasarı BPA ve BPS'nin 0.1, 0.5, 1, 5, 10 ve 50 µM konsantrasyonlarda MCF7 hücre hattında COMET yöntemi ile belirlenmiştir. Sonuç ve Tartışma: Çalışılan tüm BPA ve BPS konsantrasyonları (0.1, 0.5, 1, 5, 10 ve 50 µM) MCF7 hücre hattında kontrole kıyasla önemli ölçüde DNA hasarına neden olmuştur (p<0.05). BPS, çalışılan en yüksek 3 konsantrasyonda (5, 10 ve 50 µM) DNA hasarını BPA'dan daha fazla indüklemiştir (p<0.05). Bu çalışma bisfenol türevlerinin de BPA gibi DNA hasarına neden olabileceğini göstermektedir. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
