التفاصيل البيبلوغرافية
| العنوان: |
Creation of a biological sensorimotor interface for bionic reconstruction. |
| المؤلفون: |
Festin, Christopher, Ortmayr, Joachim, Maierhofer, Udo, Tereshenko, Vlad, Blumer, Roland, Schmoll, Martin, Carrero-Rojas, Génova, Luft, Matthias, Laengle, Gregor, Farina, Dario, Bergmeister, Konstantin D., Aszmann, Oskar C. |
| المصدر: |
Nature Communications; 6/27/2024, Vol. 15 Issue 1, p1-15, 15p |
| مصطلحات موضوعية: |
BIOLOGICAL interfaces, DORSAL root ganglia, LABORATORY rats, PERIPHERAL nervous system, NEURAL stimulation, SKELETAL muscle |
| مستخلص: |
Neuromuscular control of bionic arms has constantly improved over the past years, however, restoration of sensation remains elusive. Previous approaches to reestablish sensory feedback include tactile, electrical, and peripheral nerve stimulation, however, they cannot recreate natural, intuitive sensations. Here, we establish an experimental biological sensorimotor interface and demonstrate its potential use in neuroprosthetics. We transfer a mixed nerve to a skeletal muscle combined with glabrous dermal skin transplantation, thus forming a bi-directional communication unit in a rat model. Morphological analyses indicate reinnervation of the skin, mechanoreceptors, NMJs, and muscle spindles. Furthermore, sequential retrograde labeling reveals specific sensory reinnervation at the level of the dorsal root ganglia. Electrophysiological recordings show reproducible afferent signals upon tactile stimulation and tendon manipulation. The results demonstrate the possibility of surgically creating an interface for both decoding efferent motor control, as well as encoding afferent tactile and proprioceptive feedback, and may indicate the way forward regarding clinical translation of biological communication pathways for neuroprosthetic applications. Intuitive control of bionic arms has greatly improved over the past years, however, it is still not possible to restore natural sensory feedback. Here, the authors create a biological communication interface for both controlling a prosthesis and supplying sensations associated with the missing limb in rats. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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