التفاصيل البيبلوغرافية
| العنوان: |
Validating the Concept of Mechanical Circulatory Support with a Rotary Blood Pump in the Inferior Vena Cava in an Ovine Fontan Model. |
| المؤلفون: |
d'Udekem, Yves, Van Puyvelde, Joeri, Rega, Filip, Nix, Christoph, Barth, Svenja, Meyns, Bart |
| المصدر: |
Bioengineering (Basel); Jun2024, Vol. 11 Issue 6, p594, 8p |
| مصطلحات موضوعية: |
ARTIFICIAL blood circulation, VENA cava inferior, ROTARY pumps, VENA cava superior, PULMONARY artery, VENAE cavae |
| مستخلص: |
Right-sided mechanical support of the Fontan circulation by existing devices has been compounded by the cross-sectional design of vena cava anastomosis to both pulmonary arteries. Our purpose was to investigate whether increasing inferior vena cava (IVC) flow with a rotary blood pump in the IVC only in an ovine animal model of Fontan would lead to acceptable superior vena cava (SVC) pressure. To achieve this, a Fontan circulation was established in four female sheep by anastomosing the SVC to the main pulmonary artery (MPA) and by interposing a Dacron graft between the IVC and the MPA. A rotary blood pump was then introduced in the graft, and the effect of incremental flows was observed at increasing flow regimen. Additionally, to stimulate increased pulmonary resistance, the experience was repeated in each animal with the placement of a restrictive band on the MPA distally to the SVC and Dacron graft anastomosis. Circulatory support of IVC flow alone increased the systemic cardiac output significantly, both with and without banding, indicating the feasibility of mechanical support of the Fontan circulation by increasing the flow only in the inferior vena cava. The increase in SVC pressure remained within acceptable limits, indicating the potential effectiveness of this mode of support. The findings suggest that increasing the flow only in the inferior vena cava is a feasible method for mechanical support of the Fontan circulation, potentially leading to an increase in cardiac output with acceptable increases in superior vena cava pressure. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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