التفاصيل البيبلوغرافية
| العنوان: |
N -Methoxycarbonyl-9,12-Dimethoxy-Norchelerythrine: A Novel Antifungal Type-III Benzo[ c ]phenanthridine from Zanthoxylum simulans Hance Seedlings. |
| المؤلفون: |
Cárdenas-Laverde, Diego, Quiroga, Diego, Coy-Barrera, Ericsson |
| المصدر: |
Molbank; Jun2024, Vol. 2024 Issue 2, pM1839, 7p |
| مصطلحات موضوعية: |
PHENANTHRIDINE, ZANTHOXYLUM, NUCLEAR magnetic resonance, SEEDLINGS, ANTIFUNGAL agents, FUSARIUM oxysporum, MEDICINAL plants |
| مستخلص: |
Zanthoxylum simulans Hance, commonly known as Sichuan pepper, is a well-known medicinal plant recognized for its potential as a source of bioactive specialized metabolites. As part of our interest in natural antifungal compounds, the present study describes the discovery of an unreported N-alcoxycarbonylbenzo[c]phenanthridinium salt, N-methoxycarbonyl-9,12-dimethoxy-norchelerythrine 1 (a type-III benzo[c]phenanthridine), isolated from Z. simulans seedlings, which were propagated under controlled greenhouse conditions. Six-month seedlings were harvested and subjected to cold acid–base extraction. Chromatographic techniques achieved the isolation of 1 from raw alkaloid extract. The structural elucidation of 1 was accomplished through comprehensive spectroscopic analysis, including nuclear magnetic resonance and high-resolution mass spectrometry. Fusarium oxysporum, a fungal pathogen responsible for substantial agricultural losses, was exposed to different concentrations of the novel compound, exhibiting potent antifungal efficacy (IC50 < 3 µM) and fungicide effects. These findings highlight the potential of benzophenanthridines as antifungal leads and underscore the importance of exploring natural products for agricultural applications. [ABSTRACT FROM AUTHOR] |
|
Copyright of Molbank is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder