التفاصيل البيبلوغرافية
| العنوان: |
Mechanisms Underlying the Rarity of Skeletal Muscle Cancers. |
| المؤلفون: |
Kump, David S. |
| المصدر: |
International Journal of Molecular Sciences; Jun2024, Vol. 25 Issue 12, p6480, 28p |
| مصطلحات موضوعية: |
LACTIC acid, MYOKINES, SKELETAL muscle, EXTRACELLULAR matrix, CARCINOGENESIS, METASTASIS |
| مستخلص: |
Skeletal muscle (SKM), despite comprising ~40% of body mass, rarely manifests cancer. This review explores the mechanisms that help to explain this rarity, including unique SKM architecture and function, which prohibits the development of new cancer as well as negates potential metastasis to SKM. SKM also presents a unique immune environment that may magnify the anti-tumorigenic effect. Moreover, the SKM microenvironment manifests characteristics such as decreased extracellular matrix stiffness and altered lactic acid, pH, and oxygen levels that may interfere with tumor development. SKM also secretes anti-tumorigenic myokines and other molecules. Collectively, these mechanisms help account for the rarity of SKM cancer. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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