التفاصيل البيبلوغرافية
| العنوان: |
Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports. |
| المؤلفون: |
Zyryanov, Sergey, Asetskaya, Irina, Butranova, Olga, Terekhina, Elizaveta, Polivanov, Vitaly, Yudin, Alexander, Samsonova, Kristina |
| المصدر: |
Pharmaceuticals (14248247); Jun2024, Vol. 17 Issue 6, p675, 20p |
| مصطلحات موضوعية: |
TOXIC epidermal necrolysis, DRUG side effects, STEVENS-Johnson Syndrome, AZITHROMYCIN, DOPING in sports, DATABASES, CARBAMAZEPINE, VALPROIC acid, LACTAMS |
| مستخلص: |
(1) Background: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are extremely severe cutaneous adverse drug reactions which are relatively rare in routine clinical practice. An analysis of a national pharmacovigilance database may be the most effective method of obtaining information on SJS and TEN. (2) Methods: Design—a retrospective descriptive pharmacoepidemiologic study of spontaneous reports (SRs) with data on SJS and TEN retrieved from the Russian National Pharmacovigilance database for the period from 1 April 2019 to 31 December 2023. Descriptive statistics was used to assess the demographic data of patients and the structure of suspected drugs. (3) Results: A total of 170 SRs on SJS and TEN were identified, of which 32.9% were SJS and 67.1%—TEN. In total, 30% were pediatric SRs, 21.2%—SRs of the elderly. There were 12 lethal cases, and all cases were TEN. The leading culprit drugs were anti-infectives for systemic use and nervous system agents. The top 10 involved drugs are as follows: lamotrigine (23.5%), ibuprofen (12.9%), ceftriaxone (8.8%), amoxicillin and amoxicillin with beta-lactam inhibitors (8.8%), paracetamol (7.6%), carbamazepine (5.9%), azithromycin (4.1%), valproic acid (4.1%), omeprazole (3.5%), and levetiracetam (3.5%). (4) Conclusions: Our study was the first study in Russia aimed at the assessment of the structure of the drugs involved in SJS and TEN on the national level. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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