التفاصيل البيبلوغرافية
| العنوان: |
Vinyl-pyrazole as a biomimetic acetaldehyde surrogate. |
| المؤلفون: |
Steiner, Lorenz, Ćorović, Miljan Z., Dupé, Antoine, Mösch-Zanetti, Nadia C. |
| المصدر: |
Chemical Communications; 7/11/2024, Vol. 60 Issue 54, p6873-6876, 4p |
| مصطلحات موضوعية: |
ACETALDEHYDE, ACETYLENE, VINYLATION, AMINO acids, PYRAZOLES |
| مستخلص: |
Inspired by the enzyme acetylene hydratase, we investigated the reactivity of acetylene with tungsten(II) pyrazole complexes. Our research revealed that the complex [WBr2(pz-NHCCH3)(CO)3] (pz = 3,5-dimethyl-pyrazolate) facilitates the stochiometric reaction between pzH and acetylene to give N-vinyl-pz. This vinyl compound readily hydrolyzes to acetaldehyde, mirroring the product of acetylene hydration in the enzymatic process. The formation of the vinyl compound likely involves a reactive intermediate complex where acetylene acts as a two-electron donor, in contrast to isolable acetylene complexes that are inert to nucleophilic attack by water. Results suggest an alternative mechanism for the enzyme, including vinylation of a neighboring amino acid by acetylene in the active site prior to hydration. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
