التفاصيل البيبلوغرافية
| العنوان: |
CircRNAs in Pancreatic Cancer: New Tools for Target Identification and Therapeutic Intervention. |
| المؤلفون: |
WEIDLE, ULRICH H., NOPORA, ADAM |
| المصدر: |
Cancer Genomics & Proteomics (1109-6535); Jul/Aug2024, Vol. 21 Issue 4, p327-349, 23p |
| مصطلحات موضوعية: |
SMALL interfering RNA, PANCREATIC cancer, CIRCULAR RNA, HAIRPIN (Genetics), MEMBRANE proteins |
| مستخلص: |
We have reviewed the literature for circular RNAs (circRNAs) with efficacy in preclinical pancreatic-cancer related in vivo models. The identified circRNAs target chemoresistance mechanisms (n=5), secreted proteins and transmembrane receptors (n=15), transcription factors (n=9), components of the signaling- (n=11), ubiquitination- (n=2), autophagy-system (n=2), and others (n=9). In addition to identifying targets for therapeutic intervention, circRNAs are potential new entities for treatment of pancreatic cancer. Upregulated circRNAs can be inhibited by antisense oligonucleotides (ASO), small interfering RNAs (siRNAs), short hairpin RNAs (shRNAs) or clustered regularly interspaced short-palindromic repeats-CRISPR associated protein (CRISPR-CAS)-based intervention. The function of downregulated circRNAs can be reconstituted by replacement therapy using plasmids or virus-based vector systems. Target validation experiments and the development of improved delivery systems for corresponding agents were examined. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
