التفاصيل البيبلوغرافية
| العنوان: |
Perirhinal cortex learns a predictive map of the task environment. |
| المؤلفون: |
Lee, David G., McLachlan, Caroline A., Nogueira, Ramon, Kwon, Osung, Carey, Alanna E., House, Garrett, Lagani, Gavin D., LaMay, Danielle, Fusi, Stefano, Chen, Jerry L. |
| المصدر: |
Nature Communications; 7/2/2024, Vol. 15 Issue 1, p1-16, 16p |
| مصطلحات موضوعية: |
TASK performance, SHORT-term memory, ACETYLCHOLINE, GOAL (Psychology), STIMULUS & response (Psychology), SOMATOSENSORY cortex, CHOLINERGIC receptors |
| مستخلص: |
Goal-directed tasks involve acquiring an internal model, known as a predictive map, of relevant stimuli and associated outcomes to guide behavior. Here, we identified neural signatures of a predictive map of task behavior in perirhinal cortex (Prh). Mice learned to perform a tactile working memory task by classifying sequential whisker stimuli over multiple training stages. Chronic two-photon calcium imaging, population analysis, and computational modeling revealed that Prh encodes stimulus features as sensory prediction errors. Prh forms stable stimulus-outcome associations that can progressively be decoded earlier in the trial as training advances and that generalize as animals learn new contingencies. Stimulus-outcome associations are linked to prospective network activity encoding possible expected outcomes. This link is mediated by cholinergic signaling to guide task performance, demonstrated by acetylcholine imaging and systemic pharmacological perturbation. We propose that Prh combines error-driven and map-like properties to acquire a predictive map of learned task behavior. The neural mechanisms underlying how the brain generates internal models of the environment is not fully understood. Here authors show that mouse perirhinal cortex is involved in forming stable stimulus-outcome associations, possibly via cholinergic signaling. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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