التفاصيل البيبلوغرافية
| العنوان: |
3,3',4,4'-tetrachlorobiphenyl (PCB77) enhances human Kv1.3 channel currents and alters cytokine production. |
| المؤلفون: |
Jong-Hui Kim, Soobeen Hwang, Seo-In Park, Hyo-Ji Lee, Yu-Jin Jung, Su-Hyun Jo |
| المصدر: |
Korean Journal of Physiology & Pharmacology; Jul2024, Vol. 28 Issue 4, p323-333, 11p |
| مصطلحات موضوعية: |
POLYCHLORINATED biphenyls, CYTOKINES, INTERLEUKIN-10, IMMUNOTOXICOLOGY, SODIUM channels, CARDIOTOXICITY |
| مستخلص: |
Polychlorinated biphenyls (PCBs) were once used throughout various industries; however, because of their persistence in the environment, exposure remains a global threat to the environment and human health. The Kv1.3 and Kv1.5 channels have been implicated in the immunotoxicity and cardiotoxicity of PCBs, respectively. We determined whether 3,3',4,4'-tetrachlorobiphenyl (PCB77), a dioxin-like PCB, alters human Kv1.3 and Kv1.5 currents using the Xenopus oocyte expression system. Exposure to 10 nM PCB77 for 15 min enhanced the Kv1.3 current by approximately 30.6%, whereas PCB77 did not affect the Kv1.5 current at concentrations up to 10 nM. This increase in the Kv1.3 current was associated with slower activation and inactivation kinetics as well as right-shifting of the steady-state activation curve. Pretreatment with PCB77 significantly suppressed tumor necrosis factor-a and interleukin-10 production in lipopolysaccharide-stimulated Raw264.7 macrophages. Overall, these data suggest that acute exposure to trace concentrations of PCB77 impairs immune function, possibly by enhancing Kv1.3 currents. [ABSTRACT FROM AUTHOR] |
|
Copyright of Korean Journal of Physiology & Pharmacology is the property of Korean Society of Pharmacology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
