التفاصيل البيبلوغرافية
| العنوان: |
Electrospun SF/GO/VEGF/GAS-LP scaffolds with synergistic sequential drug release and electrical stimulation for accelerated peripheral nerve regeneration. |
| المؤلفون: |
Liu, Jiashuo, Xiang, Runzhi, Li, Hongtao, Zhu, Hong, Dang, Jiarui, Ran, Zhihui, Deng, Huan, Xu, Wenjin, Xiong, Chengjie, Huang, Zhijun, Xu, Peihu, Xu, Haixing |
| المصدر: |
International Journal of Polymeric Materials & Polymeric Biomaterials; 2024, Vol. 73 Issue 13, p1136-1148, 13p |
| مصطلحات موضوعية: |
ELECTRIC stimulation, LIPOSOMES, TISSUE scaffolds, NERVOUS system regeneration, PERIPHERAL nervous system, POLYCAPROLACTONE, VASCULAR endothelial growth factors, SILK fibroin |
| مستخلص: |
Here, a novel kind of composite scaffold was fabricated by loading vascular endothelial growth factor (VEGF) and gastrodin liposome (GAS-LP) into electrospun silk fibroin/graphene oxide(SF/GO)nanofibrous and silk fibroin sponge-filled, respectively. Our results demonstrated that VEGF and GAS exhibited different release patterns in vitro which VEGF showed rapid release rate in the first few days while GAS was released slowly and continuously as encapsulated in liposomes. The scaffolds realized the combination of intraneural vascularization drugs and electrical stimulation effectively, leading to enhanced growth of RSC96 cells. Furthermore, the scaffolds could protect RSC96 cells in an inflammatory environment. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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