التفاصيل البيبلوغرافية
| العنوان: |
Immunomodulatory effects of Ulva-derived polysaccharides, oligosaccharides, and residues in a murine model of delayed-type hypersensitivity. |
| المؤلفون: |
Jing-Yi OU, Fang-Ling LIU, Chien-Li CHEN, Ming-Chih FANG, Chung-Hsiung HUANG |
| المصدر: |
Bioscience of Microbiota, Food & Health; 2024, Vol. 43 Issue 2, p128-134, 7p |
| مصطلحات موضوعية: |
EDIBLE greens, ALLERGIES, ORAL drug administration, OLIGOSACCHARIDES, GREEN algae, ULVA, POLYSACCHARIDES |
| مستخلص: |
Ulva, an edible green alga, contains sulfated polysaccharides and oligosaccharides that possess immunomodulatory and anti-inflammatory properties. The objective of this study was to investigate the anti-allergic effects of Ulva-derived samples of polysaccharides (UP), oligosaccharides (UO), and residues (UR) on delayed-type hypersensitivity (DTH) in mice. Oral treatment of mice with UP, UO, and UR (250 mg/kg body weight) daily noticeably improved the DTH reaction as evidenced by attenuation of footpad swelling and cell infiltration at the allergen-challenge site. Although the Ulva samples had limited impacts on the production of serum total IgG, decreased concentrations of allergen-specific IgG and IgG2a and an increased concentration of IgG1 were observed in the treated mice. Moreover, treatment with them suppressed allergen-induced IFN-γ and TNF-α secretion and elevated IL-4 secretion. However, none of the Ulva sample treatments could modulate the production of IL-10. Concordantly, the in situ data reveal that the Ulva sample treatments suppressed IFN-γ and TNF-α expression at the allergen-injection site. These findings collectively suggest the potential of UP, UO, and UR as functional food candidates for the management of delayed-type hypersensitivity. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
