التفاصيل البيبلوغرافية
| العنوان: |
Novel perspectives on autophagy-oxidative stressinflammation axis in the orchestration of adipogenesis. |
| المؤلفون: |
Chun Hong, Xinming Li, Kunli Zhang, Qiuyan Huang, Baohong Li, Haiyun Xin, Bin Hu, Fanming Meng, Xiangxing Zhu, Dongsheng Tang, Chuanhuo Hu, Chenyu Tao, Jianhao Li, Yang Cao, Hai Wang, Bo Deng, Sutian Wang |
| المصدر: |
Frontiers in Endocrinology; 2024, p1-17, 17p |
| مصطلحات موضوعية: |
ADIPOGENESIS, MESENCHYMAL stem cells, CELL anatomy, REACTIVE oxygen species, ADIPOSE tissues, DRUG target |
| مستخلص: |
Adipose tissue, an indispensable organ, fulfils the pivotal role of energy storage and metabolism and is instrumental in maintaining the dynamic equilibrium of energy and health of the organism. Adipocyte hypertrophy and adipocyte hyperplasia (adipogenesis) are the two primary mechanisms of fat deposition. Mature adipocytes are obtained by differentiating mesenchymal stem cells into preadipocytes and redifferentiation. However, the mechanisms orchestrating adipogenesis remain unclear. Autophagy, an alternative cell death pathway that sustains intracellular energy homeostasis through the degradation of cellular components, is implicated in regulating adipogenesis. Furthermore, adipose tissue functions as an endocrine organ, producing various cytokines, and certain inflammatory factors, in turn, modulate autophagy and adipogenesis. Additionally, autophagy influences intracellular redox homeostasis by regulating reactive oxygen species, which play pivotal roles in adipogenesis. There is a growing interest in exploring the involvement of autophagy, inflammation, and oxidative stress in adipogenesis. The present manuscript reviews the impact of autophagy, oxidative stress, and inflammation on the regulation of adipogenesis and, for the first time, discusses their interactions during adipogenesis. An integrated analysis of the role of autophagy, inflammation and oxidative stress will contribute to elucidating the mechanisms of adipogenesis and expediting the exploration of molecular targets for treating obesity-related metabolic disorders. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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