التفاصيل البيبلوغرافية
| العنوان: |
The Role of Lutheran/Basal Cell Adhesion Molecule in Hematological Diseases and Tumors. |
| المؤلفون: |
Jin, Juan, Guo, Qinqin, Yan, Zhibin |
| المصدر: |
International Journal of Molecular Sciences; Jul2024, Vol. 25 Issue 13, p7268, 14p |
| مصطلحات موضوعية: |
CELL adhesion molecules, BLOOD diseases, CELL adhesion, CELL migration, ERYTHROCYTES, LUTHERANS, CELL motility |
| مستخلص: |
Cell adhesion is a dynamic process that plays a fundamental role in cell proliferation, maintenance, differentiation, and migration. Basal cell adhesion molecule (BCAM), also known as Lutheran (Lu), belongs to the immunoglobulin superfamily of cell adhesion molecules. Lu/BCAM, which is widely expressed in red blood cells, endothelial cells, smooth muscle cells and epithelial cells across various tissues, playing a crucial role in many cellular processes, including cell adhesion, cell motility and cell migration. Moreover, Lu/BCAM, dysregulated in many diseases, such as blood diseases and various types of cancer, may act as a biomarker and target for the treatment of these diseases. This review explores the significance of Lu/BCAM in cell adhesion and its potential as a novel target for treating hematological diseases and tumors. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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