التفاصيل البيبلوغرافية
| العنوان: |
DHXT1 , a Virulence Factor of Dactylellina haptotyla , Regulates Pathogenicity by Participating in Trap Formation and Metabolite Synthesis. |
| المؤلفون: |
Wen, Xing-Fu, Shi, Ting-Ting, Zhang, Ya-Qi, Wang, Si-Han, Xiang, Chun-Mei, Zhao, Pei-Ji |
| المصدر: |
International Journal of Molecular Sciences; Jul2024, Vol. 25 Issue 13, p7384, 12p |
| مصطلحات موضوعية: |
GENETIC overexpression, NEMATODE-destroying fungi, CRYPTOCOCCUS neoformans, INSECT nematodes, QUORUM sensing, METABOLOMICS, ADHESIVES |
| مستخلص: |
The capsule-associated protein 10 gene (CAP10) is indispensable due to its involvement in pod formation and virulence maintenance in Cryptococcus neoformans. The function of the CAP10 gene in nematode-predatory fungi remains unreported. As a typical nematode-trapping fungus, Dactylellina haptotyla efficiently captures nematodes using adhesive knobs, which has potential applications in the biological control of plant-parasitic nematodes. In this study, we investigated the function of DHXT1 (a CAP10 homologous protein) in D. haptotyla–nematode interactions based on the disruption and overexpression of DHXT1, phenotypic analysis and metabolomic analysis. As a result, it was shown that the disruption of the DHXT1 gene causes a marked decrease in the number of adhesive knobs, and on the contrary, the overexpression of the DHXT1 gene causes a substantial increase in the number of adhesive knobs. Interestingly, the variety of metabolites increased with the disruption of the DHXT1 and decreased with the overexpression of the DHXT1 gene. The results suggest that DHXT1 effects pathogenicity through its involvement in adhesive knobs' formation and metabolite synthesis and serves as a key virulence factor in D. haptotyla. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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