التفاصيل البيبلوغرافية
| العنوان: |
An Insulin-Modified pH-Responsive Nanopipette Based on Ion Current Rectification. |
| المؤلفون: |
Wang, Xu-Fan, Duan, Yi-Fan, Zhu, Yue-Qian, Liu, Zi-Jing, Wu, Yu-Chen, Liu, Tian-Hao, Zhang, Ling, Wei, Jian-Feng, Liu, Guo-Chang |
| المصدر: |
Sensors (14248220); Jul2024, Vol. 24 Issue 13, p4264, 11p |
| مصطلحات موضوعية: |
IONS, SILANIZATION, AMIDATION, INSULIN, PH effect |
| مستخلص: |
The properties of nanopipettes largely rely on the materials introduced onto their inner walls, which allow for a vast extension of their sensing capabilities. The challenge of simultaneously enhancing the sensitivity and selectivity of nanopipettes for pH sensing remains, hindering their practical applications. Herein, we report insulin-modified nanopipettes with excellent pH response performances, which were prepared by introducing insulin onto their inner walls via a two-step reaction involving silanization and amidation. The pH response intensity based on ion current rectification was significantly enhanced by approximately 4.29 times when utilizing insulin-modified nanopipettes compared with bare ones, demonstrating a linear response within the pH range of 2.50 to 7.80. In addition, insulin-modified nanopipettes featured good reversibility and selectivity. The modification processes were monitored using the I-V curves, and the relevant mechanisms were discussed. The effects of solution pH and insulin concentration on the modification results were investigated to achieve optimal insulin introduction. This study showed that the pH response behavior of nanopipettes can be greatly improved by introducing versatile molecules onto the inner walls, thereby contributing to the development and utilization of pH-responsive nanopipettes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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