التفاصيل البيبلوغرافية
العنوان: |
The synthesis of oligomers containing alternating C-glycosyl α-amino acids and proteinogenic α-amino acids. |
المؤلفون: |
Colić, Ivana, Bogović, Barbara, Jerić, Ivanka |
المصدر: |
New Journal of Chemistry; 7/28/2024, Vol. 48 Issue 28, p12584-12590, 7p |
مصطلحات موضوعية: |
OLIGOMERIZATION, ACIDS, OLIGOMERS, GALACTOMANNANS, AMINO acids |
مستخلص: |
C-Glycosyl amino acids are a group of C-glycosides in which a carbohydrate molecule is attached to the side chain or backbone of the amino acid via a C–C bond. Despite the numerous methods that have been developed for their synthesis, the C-glycosyl α-amino acids and their oligomers are relatively unexplored. In this work, we presented a protocol for the synthesis of oligomers containing alternating C-glycosyl α-amino acids and proteinogenic α-amino acids. The methodology is based on the modification of α-acyloxyamides obtained from the Passerini reaction using α- D -galactopyranose- and α- L -sorbofuranose-derived aldehydes as C-glycosyl donors. The protocol enabled the synthesis of homo- and heterochiral tetramers, and homo- and heterovalent tetramers in very good yields. [ABSTRACT FROM AUTHOR] |
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قاعدة البيانات: |
Complementary Index |