التفاصيل البيبلوغرافية
| العنوان: |
SPATIAL EXPRESSION OF ZEB1 GENE AS A POTENTIAL PROGNOSTIC MARKER IN RECTAL CANCER. |
| المؤلفون: |
Bojana, Kožik, Lidija, Todorović, Ana, Božović, Ana, Kolaković, Tijana, Vasiljević, Aleksandar, Đermanović, Mladen, Đurić, Vesna, Mandušić |
| المصدر: |
Genetics & Applications; 2024 Special Issue, p25-25, 1p |
| مصطلحات موضوعية: |
PROGNOSIS, RECTAL cancer, GENE expression, TUMOR markers, RECTUM tumors, OVERALL survival, TUMOR classification |
| مستخلص: |
The prognosis of rectal cancer (RC) can be influenced by various factors, including the location of the tumor. Studies have shown that the position of the tumor within the rectum can impact the recurrence and overall survival rates. Tumor localization in RC is also associated with gene expression alterations. ZEB1 is a transcriptional factor that promotes tumor invasiveness via regulation of the epithelial-mesenchymal transition process and plays a significant role in RC by influencing tumor aggressiveness. This study aimed to evaluate the location-specific expression of the ZEB1 gene and its prognostic role in RC patients. This preliminary study included 45 untreated RC patients who underwent curative resection. In 10 patients, the tumor was located in the low rectum (0-5 cm), while 35 tumors were positioned within the mid and upper rectum (5-15 cm). We isolated mRNA from postoperative tumor FFPE samples. TaqMan® gene expression assay was used for quantitative real-time PCR analysis of ZEB1 gene expression. The preliminary analysis revealed that relative ZEB1 gene expression was significantly higher in upper RC locations than among low-positioned tumors (0.00198 vs. 0.000947, p=0.024). We did not find a significant difference in overall survival (OS) and disease-free survival (DFS) among RC patients based on the tumor location and ZEB1 expression (p > 0.05 in both cases). However, among 35 patients with upper-positioned tumors, we noted that patients with elevated ZEB1 expression had shorter DFS than patients with low ZEB1 expression (48.062±6.557 vs. 61.682±6.095 months), although the observed difference was not statistically significant (p=0.270). Our results indicate the importance of evaluating spatial ZEB1 expression in RC and suggest its potential prognostic role, especially in determining the survival time without disease recurrence in RC patients. However, further research on a larger number of samples is needed to confirm these findings. [ABSTRACT FROM AUTHOR] |
|
Copyright of Genetics & Applications is the property of Genetics & Applications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder