التفاصيل البيبلوغرافية
| العنوان: |
Polymorphism of the BMP15 and GDF9 genes in Romanov, Wrzosówka, and Podhale Zackel sheep in Poland. |
| المؤلفون: |
Smołucha, Grzegorz, Piestrzyńska-Kajtoch, Agata, Szmatoła, Tomasz |
| المصدر: |
Animal Science & Genetics; 2024, Vol. 20 Issue 2, p63-77, 15p |
| مصطلحات موضوعية: |
SINGLE nucleotide polymorphisms, SHEEP breeds, TRANSFORMING growth factors-beta, FERTILITY, GENETIC mutation |
| مستخلص: |
Various mutations in the BMP15 and GDF9 genes belonging to the transforming growth factor-β (TGF-β) superfamily have been shown to affect prolificacy in sheep. Increasing litter size is critical to the profitability of sheep production, but it is only one of many factors that make sheep farming profitable. The study aimed to identify polymorphisms in BMP15 and GDF9 in the Romanov, Wrzosówka, and Podhale Zackel sheep breeds. Polymorphism of the coding parts of the BMP15 and GDF9 genes was determined based on DNA Sanger sequence analysis. Statistical analysis showed a significant relationship (p ≤ 0.05) between the leucine deletion identified at the BMP15 locus (c.28_30delCTT) and increased fertility in heterozygous sheep. Statistically significant differences in the level of fertility were also identified between individuals with a mutation in the GDF9 gene (c.978A> G or G6 - c.994G> A) and carriers of mutations in the BMP15 and GDF9 genes simultaneously. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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