التفاصيل البيبلوغرافية
| العنوان: |
Reaction, Recognition, Relay: Anhydride Hydrolysis Reported by Conformationally Responsive Fluorinated Foldamers in Micelles. |
| المؤلفون: |
Doerner, Benedicte, della Sala, Flavio, Wang, Siyuan, Webb, Simon J. |
| المصدر: |
Angewandte Chemie International Edition; 7/22/2024, Vol. 63 Issue 30, p1-7, 7p |
| مصطلحات موضوعية: |
RACEMIC mixtures, HYDROLYSIS, ARTIFICIAL membranes, NUCLEAR magnetic resonance spectroscopy, PROTEIN receptors, ORGANIC solvents, MICELLES, SYNTHETIC receptors |
| مستخلص: |
Natural membrane receptors are proteins that can report on changes in the concentration of external chemical messengers. Messenger binding to a receptor produces conformational changes that are relayed through the membrane into the cell; this information allows cells to adapt to changes in their environment. Artificial membrane receptors (R)‐1 and (S)‐1 are helical α‐aminoisobutyric acid (Aib) foldamers that replicate key parts of this information relay. Solution‐phase 19F NMR spectroscopy of zinc(II)‐capped receptor 1, either in organic solvent or in membrane‐mimetic micelles, showed messenger binding produced an enrichment of either left‐ or right‐handed screw‐sense; the chirality of the bound messenger was relayed to the other receptor terminus. Furthermore, in situ production of a chemical messenger in the external aqueous environment could be detected in real‐time by a racemic mixture of receptor 1 in micelles. The hydrolysis of insoluble anhydrides produced carboxylate in the aqueous phase, which bound to the receptors and gave a distinct 19F NMR output from inside the hydrophobic region of the micelles. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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