التفاصيل البيبلوغرافية
| العنوان: |
Population pharmacokinetics of tamsulosine in patients with benign prostatic hyperplasia. |
| المؤلفون: |
Nikolic, Valentina N., Jankovic, Slobodan M., Vujovic, Maja, Sterovic, Srdjan, Dinic, Ljubomir A., Milovanovic, Jasmina R. |
| المصدر: |
World Journal of Urology; 7/22/2024, Vol. 42 Issue 1, p1-7, 7p |
| مصطلحات موضوعية: |
BENIGN prostatic hyperplasia, LIQUID chromatography-mass spectrometry, ADRENERGIC alpha blockers, PHARMACOKINETICS, TAMSULOSIN |
| مستخلص: |
Purpose: The study aimed to determine the typical clearance and volume of distribution values of tamsulosin in patients with benign prostatic hyperplasia (BPH), and to identify factors with a measurable impact on the drug's elimination. Methods: This open-label, single-arm population pharmacokinetic study involved 65 adult men with BPH who had been on tamsulosin therapy for at least seven days. The steady-state serum concentrations of tamsulosin were measured using liquid chromatography-tandem quadrupole mass spectrometry. Population pharmacokinetic parameters, their variability, and influencing factors were estimated based on a two-compartment pharmacokinetic model using NONMEM software. Results: The estimated tamsulosin clearance in BPH patients was 0.719 L/h, and the steady-state volume of distribution was 32 L. Neither renal nor liver function parameters had a statistically significant effect on tamsulosin clearance. However, a positive correlation was observed between hemoglobin levels and tamsulosin clearance in the BPH patient cohort. Conclusion: Our investigation reveals significant associations between tamsulosin pharmacokinetics and specific characteristics of patients with lower urinary tract symptoms (LUTS) due to BPH. The study highlights that tamsulosin clearance is associated with hemoglobin levels in patients with LUTS/BPH. This study underscores the importance of considering patient-specific factors when managing BPH treatment with tamsulosin, emphasizing associations rather than causative relationships. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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