التفاصيل البيبلوغرافية
| العنوان: |
N‐Heterocyclic Carbene Catalyzed Stetter–Aldol Domino Cyclization To Synthesize Tetrahydronaphthalene‐Fused Spirooxindoles. |
| المؤلفون: |
Xu, Qiuling, Cui, Qinghong, He, Xiaoshan, Sun, Ruifen, Wang, Junliang |
| المصدر: |
European Journal of Organic Chemistry; 7/22/2024, Vol. 27 Issue 28, p1-5, 5p |
| مصطلحات موضوعية: |
DERACEMIZATION, RING formation (Chemistry), ALDOLS, ORGANIC bases, ANNULATION, CARBENES |
| مستخلص: |
A formal [4+2] annulation reaction of phthalaldehydes and 3‐ylideneoxindoles through a tandem process of a Stetter–aldol reaction was accomplished by the application N‐heterocyclic carbenes as effective catalysts. Under mild conditions, this unprecedented cascade reaction readily occurs in good yield, enabling straightforward access to functionalized tetrahydronaphthalene‐fused spirooxindoles. For the first time, the feasibility of an asymmetric Stetter–aldol reaction has also been briefly explored by employing chiral organic bases to promote the asymmetric transformation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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