التفاصيل البيبلوغرافية
| العنوان: |
Acute neuroinflammation promotes a metabolic shift that alters extracellular vesicle cargo in the mouse brain cortex. |
| المؤلفون: |
Vassileff, Natasha, Spiers, Jereme G., Juliani, Juliani, Lowe, Rohan G. T., Datta, Keshava K., Hill, Andrew F. |
| المصدر: |
Journal of Extracellular Biology; Jul2024, Vol. 3 Issue 7, p1-13, 13p |
| مستخلص: |
Neuroinflammation is initiated through microglial activation and cytokine release which can be induced through lipopolysaccharide treatment (LPS) leading to a transcriptional cascade culminating in the differential expression of target proteins. These differentially expressed proteins can then be packaged into extracellular vesicles (EVs), a form of cellular communication, further propagating the neuroinflammatory response over long distances. Despite this, the EV proteome in the brain, following LPS treatment, has not been investigated. Brain tissue and brain derived EVs (BDEVs) isolated from the cortex of LPS‐treated mice underwent thorough characterisation to meet the minimal information for studies of extracellular vesicles guidelines before undergoing mass spectrometry analysis to identify the differentially expressed proteins. Fourteen differentially expressed proteins were identified in the LPS brain tissue samples compared to the controls and 57 were identified in the BDEVs isolated from the LPS treated mice compared to the controls. This included proteins associated with the initiation of the inflammatory response, epigenetic regulation, and metabolism. These results allude to a potential link between small EV cargo and early inflammatory signalling. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Extracellular Biology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder