التفاصيل البيبلوغرافية
| العنوان: |
The Beak of Eukaryotic Ribosomes: Life, Work and Miracles. |
| المؤلفون: |
Martín-Villanueva, Sara, Galmozzi, Carla V., Ruger-Herreros, Carmen, Kressler, Dieter, de la Cruz, Jesús |
| المصدر: |
Biomolecules (2218-273X); Jul2024, Vol. 14 Issue 7, p882, 27p |
| مصطلحات موضوعية: |
RIBOSOMAL RNA, ORGANELLE formation, GENETIC translation, RIBOSOMES, BEAKS, RIBOSOMAL proteins |
| مستخلص: |
Ribosomes are not totally globular machines. Instead, they comprise prominent structural protrusions and a myriad of tentacle-like projections, which are frequently made up of ribosomal RNA expansion segments and N- or C-terminal extensions of ribosomal proteins. This is more evident in higher eukaryotic ribosomes. One of the most characteristic protrusions, present in small ribosomal subunits in all three domains of life, is the so-called beak, which is relevant for the function and regulation of the ribosome's activities. During evolution, the beak has transitioned from an all ribosomal RNA structure (helix h33 in 16S rRNA) in bacteria, to an arrangement formed by three ribosomal proteins, eS10, eS12 and eS31, and a smaller h33 ribosomal RNA in eukaryotes. In this review, we describe the different structural and functional properties of the eukaryotic beak. We discuss the state-of-the-art concerning its composition and functional significance, including other processes apparently not related to translation, and the dynamics of its assembly in yeast and human cells. Moreover, we outline the current view about the relevance of the beak's components in human diseases, especially in ribosomopathies and cancer. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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