التفاصيل البيبلوغرافية
| العنوان: |
Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells. |
| المؤلفون: |
Mukusheva, Gulim K., Jalmakhanbetova, Roza I., Shaibek, Altynay Zh., Nurmaganbetova, Manshuk S., Zhasymbekova, Aigerym R., Nurkenov, Oralgazy A., Akishina, Ekaterina A., Kolesnik, Irina A., Dikusar, Evgenij A., Terpinskaya, Tatiana I., Kulchitsky, Vladimir A., Potkin, Vladimir I., Pushkarchuk, Alexander L., Lyakhov, Dmitry A., Michels, Dominik L. |
| المصدر: |
Molecules; Jul2024, Vol. 29 Issue 14, p3246, 16p |
| مصطلحات موضوعية: |
ANTINEOPLASTIC combined chemotherapy protocols, LABORATORY rats, DRUG synergism, ANTINEOPLASTIC agents, CHEMICAL models |
| مستخلص: |
Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting C6 rat glioma model cells. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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