التفاصيل البيبلوغرافية
| العنوان: |
Genome Characterization and Phylogenetic Analysis of Scale Drop Disease Virus Isolated from Asian Seabass (Lates calcarifer). |
| المؤلفون: |
Chokmangmeepisarn, Putita, Azmai, Mohammad Noor Amal, Domingos, Jose A., van Aerle, Ronny, Bass, David, Prukbenjakul, Pochara, Senapin, Saengchan, Rodkhum, Channarong |
| المصدر: |
Animals (2076-2615); Jul2024, Vol. 14 Issue 14, p2097, 19p |
| مستخلص: |
Simple Summary: Scale drop disease virus (SDDV) has been identified as a significant pathogen causing scale drop syndrome (SDS), leading to significant economic losses in Asian seabass production in Southeast Asia. This study utilized a metagenomic approach to investigate the bacterial and viral communities associated with SDS, with a particular focus on SDDV, and evaluated the potential of metagenomics for retrieving complete SDDV genomes. By characterizing the complete genomes of SDDV strains, we aimed to gain a deeper understanding of the virus. The insights gained from this study are expected to inform the development of comprehensive disease prevention and control strategies for SDDV, mitigating its impact on the aquaculture industry. Scale drop disease virus (SDDV), a double-stranded DNA virus in the family Iridoviridae, has been reported widely in southeast Asian countries as a causative agent of scale drop syndrome (SDS) in Asian seabass. SDS has resulted in high mortality and significant economic losses to the aquaculture industry. This study demonstrated the use of metagenomic methods to investigate bacterial and viral communities present in infected fish tissues and recover a complete genome of the causative agent named SDDV TH7_2019. Characterization of the TH7_2019 genome revealed a genome size of 131 kb with 134 putative ORFs encoding viral proteins potentially associated with host apoptosis manipulation. A comparative genome analysis showed a high degree of amino acid identity across SDDV strains, with variations in number of repeat sequences and mutations within core genes. Phylogenetic analyses indicate a close relationship among SDDV genomes. This research enhances our understanding of the genetic diversity and evolutionary relationship of SDDV, contributing valuable insights for further development of effective control strategies of SDDV. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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