التفاصيل البيبلوغرافية
| العنوان: |
Breaking the mould: challenging the status quo of clinical trial response definitions for invasive fungal diseases—a debate. |
| المؤلفون: |
Maertens, Johan, Slavin, Monica, Hoenigl, Martin, Thompson, George R, Richardson, Malcolm, Lass-Flörl, Cornelia |
| المصدر: |
Journal of Antimicrobial Chemotherapy (JAC); Aug2024, Vol. 79 Issue 8, p1786-1793, 8p |
| مصطلحات موضوعية: |
CHRONIC granulomatous disease, TREATMENT effectiveness, CENTRAL nervous system diseases, POSITRON emission tomography, INVASIVE candidiasis |
| مستخلص: |
The article explores the need for updated and standardized definitions for assessing treatment response in clinical trials for invasive fungal diseases (IFD). The current definitions, established in 2008, may not accurately capture the complexities of evaluating antifungal efficacy in patients with mold disease. This could potentially impact the evaluation and approval of new antifungal agents. The article presents arguments for and against updating the definitions, emphasizing the importance of clear and non-subjective criteria for standardized assessment in clinical trials. The article also discusses the limitations of the current definitions and proposes potential improvements, such as incorporating new assessment methods and considering diverse patient populations. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
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