التفاصيل البيبلوغرافية
| العنوان: |
The oncogenic roles of GPR176 in ovarian cancer: a molecular target for aggressiveness and gene therapy. |
| المؤلفون: |
Ning Yang, Wen-jing Yun, Zheng-guo Cui, Hua-chuan Zheng |
| المصدر: |
Journal of Obstetrics & Gynaecology; Dec2024, Vol. 44 Issue 1, p1-9, 9p |
| مصطلحات موضوعية: |
CELL adhesion molecules, GENE expression, OVARIAN cancer, FOCAL adhesions, OVARIES |
| مستخلص: |
Background: At present, the discovery of new biomarkers is of great significance for the early diagnosis, treatment and prognosis assessment of ovarian cancer. Previous findings indicated that aberrant G-protein-coupled receptor 176 (GPR176) expression might contribute to tumorigenesis and subsequent progression. However, the expression of GPR176 and the molecular mechanisms in ovarian cancer had not been investigated. Methods: GPR176 expression was compared with clinicopathological features of ovarian cancer using immunohistochemical and bioinformatics analyses. GPR176-related genes and pathways were analysed using bioinformatics analysis. additionally, the effects of GPR176 on ovarian cancer cell phenotypes were investigated. Results: GPR176 expression positively correlated with elder age, clinicopathological staging, tumour residual status, and unfavourable survival of ovarian cancer, but negatively with purity loss, infiltration of B cells, and CD8+ T cells. Gene Set enrichment analysis showed that differential expression of GPR176 was involved in focal adhesion, eCM-receptor interaction, cell adhesion molecules and so on. STRING and Cytoscape were used to determine the top 10 nodes. Kyoto encyclopaedia of Genes and Genomes analysis indicated that GPR176-related genes were involved in the ECM structural constituent and organisation and so on. GPR176 overexpression promoted the proliferation, anti-apoptosis, anti-pyroptosis, migration and invasion of ovarian cancer cells with overexpression of N-cadherin, Zeb1, Snail, Twist1, and under-expression of gasdermin D, caspase 1, and e-cadherin. Conclusion: GPR176 might be involved in the progression of ovarian cancer. It might be used as a biomarker to indicate the aggressive behaviour and poor prognosis of ovarian cancer and a target of genetic therapy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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