التفاصيل البيبلوغرافية
| العنوان: |
Age-Related Differences in Neutralizing Antibody Responses against SARS-CoV-2 Delta and Omicron Variants in 151 SARS-CoV-2-Naïve Metropolitan Residents Boosted with BNT162b2. |
| المؤلفون: |
Beomki Lee, Go Eun Bae, In Hwa Jeong, Jong-Hun Kim, Min-Jung Kwon, Jayoung Kim, Byoungguk Kim, June-Woo Lee, Jeong-Hyun Nam, Hee Jin Huh, Eun-Suk Kang |
| المصدر: |
Journal of Applied Laboratory Medicine; Jul2024, Vol. 9 Issue 4, p741-751, 11p |
| مصطلحات موضوعية: |
SARS-CoV-2 Omicron variant, SARS-CoV-2 Delta variant, OLDER people, BINDING site assay, ANTIBODY titer, YOUNG adults, MIDDLE-aged persons |
| مستخلص: |
Background: Although age negatively correlates with vaccine-induced immune responses, whether the vaccineinduced neutralizing effect against variants of concern (VOCs) substantially differs across age remains relatively poorly explored. In addition, the utility of commercial binding assays developed with the wild-type SARS-CoV-2 for predicting the neutralizing effect against VOCs should be revalidated. Methods: We analyzed 151 triple-vaccinated SARS-CoV-2-naïve individuals boosted with BNT162b2 (Pfizer-BioNTech). The study population was divided into young adults (age < 30), middle-aged adults (30 ≤ age < 60), and older adults (age ≤ 60). The plaque reduction neutralization test (PRNT) titers against Delta (B.1.617.2) and Omicron (B.1.1.529) variants were compared across age. Antibody titers measured with commercial binding assays were compared with PRNT titers. Results: Age-related decline in neutralizing titers was observed for both Delta and Omicron variants. Neutralizing titers for Omicron were lower than those against Delta in all ages. The multiple linear regression model demonstrated that duration from third dose to sample collection and vaccine types were also significant factors affecting vaccine-induced immunity along with age. The correlation between commercial binding assays and PRNT was acceptable for all age groups with the Delta variant, but relatively poor for middle-aged and older adults with the Omicron variant due to low titers. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Applied Laboratory Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
