التفاصيل البيبلوغرافية
| العنوان: |
Exposure to per- and polyfluoroalkyl substances and breast cancer risk: a systematic review and meta-analysis of epidemiologic studies. |
| المؤلفون: |
Chang, Che-Jung, Ish, Jennifer L, Chang, Vicky C, Daniel, Meklit, Jones, Rena R, White, Alexandra J |
| المصدر: |
American Journal of Epidemiology; Aug2024, Vol. 193 Issue 8, p1182-1196, 15p |
| مصطلحات موضوعية: |
BREAST tumor risk factors, RISK assessment, HORMONE receptor positive breast cancer, RESEARCH funding, META-analysis, DESCRIPTIVE statistics, POSTMENOPAUSE, SYSTEMATIC reviews, CONFIDENCE intervals, COMPARATIVE studies, FLUOROCARBONS, CELL receptors |
| مستخلص: |
We synthesized the epidemiologic evidence on the associations between per- and polyfluoroalkyl substances (PFAS) exposure and breast cancer risk. Our systematic review and meta-analysis included 18 and 11 articles, respectively, covering studies up to February 2023. The summary relative risks (RRs) estimated by random-effects meta-analyses did not support an association between PFAS and overall breast cancer risk (eg, a natural log (ln)-unit increase in serum/plasma concentrations [ng/mL] for perfluorooctanoate [PFOA] RR = 0.95; 95% CI, 0.77-1.18; perfluorooctane sulfonate [PFOS] RR = 0.98; 95% CI, 0.87-1.11). However, when limiting to studies that assessed exposures prior to a breast cancer diagnosis, we observed a positive association with PFOA (a ln-unit increase, RR = 1.16; 95% CI, 0.96-1.40). We also observed some possible heterogeneous associations by tumor estrogen and progesterone receptor status among postmenopausal breast cancer cases. No meaningful changes were observed after excluding the studies with high risk of bias (Tier 3). Based on the evaluation tool developed by the National Toxicology Program, given the heterogeneity across studies and the variability in timing of exposure measurements, the epidemiologic evidence needed to determine the association between PFAS exposure and breast cancer remains inadequate. Our findings support the need for future studies with improved study designs to determine this association. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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