التفاصيل البيبلوغرافية
| العنوان: |
Comorbidity profiling identifies potential subtype of elderly patients with nasopharyngeal carcinoma. |
| المؤلفون: |
Li, Ying, Pan, Yuhui, Huang, Zongwei, Wu, Lishui, Wu, Wenxi, Xu, Siqi, Chen, Zihan, Chen, Xin, Lu, Jun, Qiu, Sufang |
| المصدر: |
Oncologist; Aug2024, Vol. 29 Issue 8, pe1020-e1030, 11p |
| مصطلحات موضوعية: |
MORTALITY risk factors, RISK assessment, METABOLIC disorders, SURVIVAL rate, PREDICTION models, RESEARCH funding, CANCER relapse, STRUCTURAL equation modeling, DESCRIPTIVE statistics, MANN Whitney U Test, CHI-squared test, CANCER patients, KAPLAN-Meier estimator, LOG-rank test, NASOPHARYNX cancer, COMPARATIVE studies, DATA analysis software, CONFIDENCE intervals, COMORBIDITY, PROPORTIONAL hazards models, OLD age |
| مصطلحات جغرافية: |
CHINA |
| مستخلص: |
Background Few studies have assessed the comprehensive associations among comorbid diseases in elderly patients with nasopharyngeal carcinoma (NPC). This study sought to identify potential comorbidity patterns and explore the relationship of comorbidity patterns with the mortality risk in elderly patients with NPC. Methods A total of 452 elderly patients with NPC were enrolled in the study. The network analysis and latent class analysis were applied to mine comorbidity patterns. Propensity score matching was used for adjusting confounders. A restricted cubic spline model was used to analyze the nonlinear association between age and the risk of all-cause mortality. Results We identified 2 comorbidity patterns, metabolic disease-related comorbidity (MDRC) and organ disease-related comorbidity (ODRC) in elderly patients with NPC. Patients in MDRC showed a significantly higher risk of all-cause mortality (71.41% vs 87.97%, HR 1.819 [95% CI, 1.106-2.994], P = .031) and locoregional relapse (68.73% vs 80.88%, HR 1.689 [95% CI, 1.055-2.704], P = .042). Moreover, in patients with MDRC pattern, we observed an intriguing inverted S-shaped relationship between age and all-cause mortality among patients aged 68 years and older. The risk of mortality up perpetually with age increasing in ODRC group, specifically within the age range of 68-77 years (HR 4.371, 1.958-9.757). Conclusion Our study shed light on the potential comorbidity patterns in elderly patients with NPC, thereby providing valuable insights into the development of comprehensive health management strategies for this specific population. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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