التفاصيل البيبلوغرافية
| العنوان: |
N -(2-Hydroxyphenyl)-2-Propylpentanamide (HO-AAVPA) Induces Apoptosis and Cell Cycle Arrest in Breast Cancer Cells, Decreasing GPER Expression. |
| المؤلفون: |
Prestegui Martel, Berenice, Chávez-Blanco, Alma Delia, Domínguez-Gómez, Guadalupe, Dueñas González, Alfonso, Gaona-Aguas, Patricia, Flores-Mejía, Raúl, Somilleda-Ventura, Selma Alin, Rodríguez-Cortes, Octavio, Morales-Bárcena, Rocío, Martínez Muñoz, Alberto, Mejia Barradas, Cesar Miguel, Mendieta Wejebe, Jessica Elena, Correa Basurto, José |
| المصدر: |
Molecules; Aug2024, Vol. 29 Issue 15, p3509, 13p |
| مستخلص: |
In this work, we performed anti-proliferative assays for the compound N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA) on breast cancer (BC) cells (MCF-7, SKBR3, and triple-negative BC (TNBC) MDA-MB-231 cells) to explore its pharmacological mechanism regarding the type of cell death associated with G protein-coupled estrogen receptor (GPER) expression. The results show that HO-AAVPA induces cell apoptosis at 5 h or 48 h in either estrogen-dependent (MCF-7) or -independent BC cells (SKBR3 and MDA-MB-231). At 5 h, the apoptosis rate for MCF-7 cells was 68.4% and that for MDA-MB-231 cells was 56.1%; at 48 h, that for SKBR3 was 61.6%, that for MCF-7 cells was 54.9%, and that for MDA-MB-231 (TNBC) was 43.1%. HO-AAVPA increased the S phase in MCF-7 cells and reduced the G2/M phase in MCF-7 and MDA-MB-231 cells. GPER expression decreased more than VPA in the presence of HO-AAVPA. In conclusion, the effects of HO-AAVPA on cell apoptosis could be modulated by epigenetic effects through a decrease in GPER expression. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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