التفاصيل البيبلوغرافية
| العنوان: |
Role of Csdc2 in Regulating Secondary Hair Follicle Growth in Cashmere Goats. |
| المؤلفون: |
Zhu, Heqing, Li, Yingying, Xu, He, Ma, Yuehui, Andersson, Göran, Bongcam-Rudloff, Erik, Li, Tiantian, Zhang, Jie, Li, Yan, Han, Jilong, Yang, Min |
| المصدر: |
International Journal of Molecular Sciences; Aug2024, Vol. 25 Issue 15, p8349, 14p |
| مصطلحات موضوعية: |
HAIR follicles, TRANSCRIPTION factors, GENE regulatory networks, HAIR growth, TEXTILE fibers |
| مستخلص: |
Cashmere goats possess two types of hair follicles, with the secondary hair follicles producing valuable cashmere fiber used for textiles. The growth of cashmere exhibits a seasonal pattern arising from photoperiod change. Transcription factors play crucial roles during this process. The transcription factor, cold-shock domain, containing C2 (Csdc2) plays a crucial role in modulating cell proliferation and differentiation. Our preceding research indicated that the expression of Csdc2 changes periodically during anagen to telogen. However, the mechanisms of Csdc2 in regulating SHF growth remain unclear. Here, we found that the knockdown of Csdc2 inhibits the proliferation of dermal papilla cells. ChIP-Seq analysis showed that Csdc2 had a unique DNA binding motif in SHFs. Through conjoint analysis of ChIP-Seq and RNA-Seq, we revealed a total of 25 candidate target genes of Csdc2. Notably, we discovered a putative Csdc2 binding site within roundabout guidance receptor 2 (Robo2) on chromosome 1 of the goat genome. Furthermore, qRT-PCR and dual-luciferase reporter assay confirmed Csdc2's positive regulatory influence on Robo2. These findings expand the research field of hair follicle transcriptional regulatory networks, offering insights into molecular breeding strategies to enhance cashmere production in goats. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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