التفاصيل البيبلوغرافية
| العنوان: |
Variant-Specific IgA Protects Against Omicron Infection. |
| المؤلفون: |
Goh, Yun Shan, Fong, Siew-Wai, Hor, Pei Xiang, Loh, Chiew Yee, Wang, Bei, Salleh, Siti Nazihah Mohd, Ngoh, Eve Zi Xian, Lee, Raphael Tze Chuen, Poh, Xuan Ying, Rao, Suma, Chia, Po Ying, Ong, Sean W X, Lee, Tau Hong, Lim, Clarissa, Teo, Jefanie, Pada, Surinder, Sun, Louisa Jin, Ong, Desmond Luan Seng, Somani, Jyoti, Lee, Eng Sing |
| المصدر: |
Journal of Infectious Diseases; 8/15/2024, Vol. 230 Issue 2, pe287-e291, 5p |
| مصطلحات موضوعية: |
SARS-CoV-2, BREAKTHROUGH infections, SARS-CoV-2 Omicron variant, BOOSTER vaccines, ANTIBODY formation |
| مستخلص: |
Background The emergence of rapidly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, coupled with waning vaccine-induced immunity, has contributed to the rise of vaccine breakthrough infections. It is crucial to understand how vaccine-induced protection is mediated. Methods We examined 2 prospective cohorts of mRNA vaccinated and boosted individuals during the Omicron wave of infection in Singapore. Results We found that individuals who remain uninfected over the follow-up period had a higher variant-specific IgA, but not IgG, antibody response at 1 month after booster vaccination, compared with individuals who became infected. Conclusions We conclude that IgA may have a potential contributory role in protection against Omicron infection. Clinical Trials Registration. NCT05142319. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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