التفاصيل البيبلوغرافية
| العنوان: |
Torque teno viruses exhaust and imprint the human immune system via the HLA-E/NKG2A axis. |
| المؤلفون: |
Vietzen, Hannes, Simonitsch, Cara, Friedel, Benjamin, Berger, Sarah M., Kühner, Laura M., Furlano, Philippe L., Florian, David M., Görzer, Irene, Koblischke, Maximilian, Aberle, Judith H., Puchhammer-Stöckl, Elisabeth |
| المصدر: |
Frontiers in Immunology; 2024, p1-13, 13p |
| مصطلحات موضوعية: |
TORQUE teno virus, T cells, IMMUNE system, IMMUNE response, CD8 antigen |
| مستخلص: |
The ubiquitous Torque teno virus (TTV) establishes a chronically persistent infection in the human host. TTV has not been associated with any apparent disease, but, as part of the human virome, it may confer a regulatory imprint on the human immune system with as yet unclear consequences. However, so far, only few studies have characterized the TTV-specific immune responses or the overall immunological imprints by TTV. Here, we reveal that TTV infection leads to a highly exhausted TTV-specific CD8+ T-cell response, hallmarked by decreased IFN-g production and the expression of the inhibitory NKG2Areceptor. On a functional level, we identified a panel of highly polymorphic TTV-encoded peptides that lead to an expansion of regulatory NKG2A+ natural killer, NKG2A+CD4+, and NKG2A+CD8+ T cells via the stabilization of the nonclassical HLA-E molecule. Our results thus demonstrate that TTV leads to a distinct imprint on the human immune system that may further regulate overall human immune responses in infectious, autoimmune, and malignant diseases. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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