التفاصيل البيبلوغرافية
| العنوان: |
B cells from aged mice exhibit reduced apoptosis upon B-cell antigen receptor stimulation and differential ability to up-regulate survival signals. |
| المؤلفون: |
Montes, C. L., Maletto, B. A., Rodriguez, E. V. Acosta, Gruppi, A., Pistoresi-Palencia, M. C. |
| المصدر: |
Clinical & Experimental Immunology; Jan2006, Vol. 143 Issue 1, p30-40, 11p |
| مصطلحات موضوعية: |
B cells, OLD age, APOPTOSIS, IMMUNE response, LEUCOCYTES |
| مستخلص: |
During ageing, autoimmune disorders and the higher susceptibility to infectious have been associated with alterations in the humoral immune response. We report that splenic B lymphocytes from aged mice exhibit lower level of apoptosis induced by B-cell antigen receptor (BCR) ligation in vitro. Respect to B cells from young mice the anti-µ stimulated aged B cells show similar Bcl-2 and Bcl-xL expression but differential kinetic of A1 degradation and a higher level of cFLIP and FAIM. Even though B cells from aged mice show minor Fas expression they exhibit the same susceptibility to anti-Fas induced apoptosis. Aged B cells also present upon BCR stimulation, a higher proliferative response and similar level of activation markers expression than B cells from young mice. These data agree with the observation that aged mice exhibit an increment of T2 and mature B cell subset which rapidly enters cell cycle upon BCR engagement. The diminished apoptosis after activation in aged mice could compromise homeostatic mechanism allowing the persistence of self and non-self antigen specific B cells. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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