التفاصيل البيبلوغرافية
| العنوان: |
Incidence and antimicrobial susceptibility of Porphyromonas gingivalis isolated from mixed endodontic infections. |
| المؤلفون: |
Jacinto, R. C., Gomes, B. P. F. A., Shah, H. N., Ferraz, C. C., Zaia, A. A., Souza‐Filho, F. J. |
| المصدر: |
International Endodontic Journal; Jan2006, Vol. 39 Issue 1, p62-70, 9p, 2 Charts, 1 Graph |
| مصطلحات موضوعية: |
PORPHYROMONAS gingivalis, ENDODONTICS, INFECTION, DENTAL pathology, MACROLIDE antibiotics, DENTISTRY |
| مستخلص: |
Aim To investigate the prevalence of Porphyromonas gingivalis in root canals of infected teeth with periapical abscesses and to investigate the antimicrobial susceptibility of this species to some frequently prescribed antibiotics. Methodology Samples were obtained from 70 root canals of abscessed teeth. Microbial sampling, isolation and bacterial identification were accomplished using appropriate culture methods for anaerobic species. The antimicrobial susceptibility of the 20 strains of P. gingivalis isolated was determined by using the E-test. The antimicrobial agents tested were amoxicillin, amoxicillin + clavulanate, azythromycin, benzylpenicillin, cephaclor, clindamycin, erythromycin, metronidazole and tetracycline. Results A total of 352 individual strains, belonging to 69 different species, were isolated. Eighty three percent of the strains were strict anaerobes and 47.5% of the isolated bacteria were Gram-negative. Porphyromonas gingivalis was found in 20 root canals and was most frequently found in symptomatic cases. Statistically, the presence of P. gingivalis was related to purulent exudates and pain on palpation (both P < 0.05). All P. gingivalis strains were sensitive to amoxicillin, amoxicillin + clavulanate, cephaclor, clindamycin, benzylpenicyllin, metronidazole and tetracycline. The lowest range of minimum inhibitory concentration (MIC) (0.026–0.125 μg mL−1) was observed against amoxicillin + clavulanate and clindamycin. The lowest MIC 90 was observed against clindamycin (0.064 μg mL−1). One strain was resistant to erythromycin and eight strains were resistant to azythromycin. Conclusion Porphyromonas gingivalis pathogen is isolated with frequency from root canals of infected teeth with periapical abscesses. Amoxicillin, as well as amoxicillin–clavulanic acid and benzylpenicillin were effective against P. gingivalis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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