التفاصيل البيبلوغرافية
| العنوان: |
Tamoxifen Paradoxically Decreases Paclitaxel Deposition into Cerebrospinal Fluid of Brain Tumor Patients. |
| المؤلفون: |
Johnson Chen, Casilda Balmaceda, Jeffrey Bruce, Michael Sisti, May Huang, Ying Cheung, Guy McKhann, Robert Goodman, Robert Fine |
| المصدر: |
Journal of Neuro-Oncology; Jan2006, Vol. 76 Issue 1, p85-92, 8p |
| مستخلص: |
Background: P-glycoprotein (Pgp) mediates, in part, resistance to natural product chemotherapy drugs which constitute over half of the available drugs for cancer treatment. Tamoxifen (TAM) enhances intracellular deposition of natural product chemotherapy in human cell lines by inhibition of Pgp. Pgp is highly expressed in the choroid plexus and is thought to be a key component of the bloodcerebrospinal fluid barrier (BCSFB). We conducted a prospective, randomized study to assess if Pgp inhibition by TAM alters deposition of paclitaxel in cerebrospinal fluid (CSF). [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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