التفاصيل البيبلوغرافية
| العنوان: |
Diet-induced obesity and acute hyperlipidemia reduce IicBot levels in rat skeletal muscle in a fiber-type dependent manner. |
| المؤلفون: |
Bhatt, Bankim A., Dube, John J., Dedousis, Nikolas, Reider, Jodie A., Robert M. O'Doherty |
| المصدر: |
American Journal of Physiology: Regulatory, Integrative & Comparative Physiology; Jan2006, Vol. 290, p233-240, 8p, 1 Black and White Photograph, 1 Diagram, 5 Graphs |
| مصطلحات موضوعية: |
INSULIN resistance, OBESITY, HYPERLIPIDEMIA, RATS, TRIGLYCERIDES, PHYSIOLOGY |
| مستخلص: |
Increased activity of proinflammatory/stress pathways has been implicated in the pathogenesis of insulin resistance in obesity. However, the effects of obesity on the activity of these pathways in skeletal muscle, the major insulin-sensitive tissue by mass, are poorly understood. Furthermore, the mechanisms that activate proinflammatory/stress pathways in obesity are unknown. The present study addressed the effects of diet-induced obesity (DIO; 6 wk of high-fat feeding) and acute (6-h) hyperlipidemia (HL) in rats on activity of IKK/IκB/NF-κB c-Jun NH2-terminal kinase, and p38 MAPK in three skeletal muscles differing in fiber type [superficial vastus (Vas; last twitch-glycolytic), soleus (Sol; slow twitch-oxidative), and gastrocnemius (Gas; mixed)]. DIO decreased the levels of the IκBα in Vas (24 ± 3%, P = 0.001, n = 8) but not in Sol or Gas compared with standard chow-fed controls. Similar to DIO, HL decreased IκBα levels in Vas (26 ± 5%, P = 0.006, n = 6) and in Gas (15 ± 4%, P = 0.01, n = 7) but not in Sol compared with saline-infused controls. Importantly, the fiber-type-dependent effects on IκBα levels could not be explained by differential accumulation of triglyceride in Sol and Vas. HL, but not DIO, decreased phospho-p38 MAPK levels in Vas (41 ± 7% P = 0.004, n = 6) but not in Sol or Gas. Finally, skeletal muscle c-Jun NH2-terminal kinase activity was unchanged by DIO or HL. We conclude that diet-induced obesity and acute HL reduce IκBα levels in rat skeletal muscle in a fiber-type-dependent manner. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
