التفاصيل البيبلوغرافية
| العنوان: |
Ototoxic drugs and sensorineural hearing loss following severe neonatal respiratory failure. |
| المؤلفون: |
Robertson, Charlene M. T., Tyebkhan, Juzer M., Peliowski, Abraham, Etches, Philip C., Po-Yin Cheung |
| المصدر: |
Acta Paediatrica; Feb2006, Vol. 95 Issue 2, p214-223, 10p, 6 Charts |
| مصطلحات موضوعية: |
OTOTOXIC agents, DEAFNESS in children, RESPIRATORY insufficiency in children, NEUROTOXIC agents, RESPIRATORY insufficiency, PEDIATRIC respiratory diseases, DRUG side effects, PHARMACODYNAMICS, SENSORINEURAL hearing loss |
| مستخلص: |
Aim: To determine relationships between ototoxic drugs and 4-y sensorineural hearing loss (SNHL) in near-term and term survivors of severe neonatal respiratory failure. Methods: All 81 survivors of the Canadian arm of the Neonatal Inhaled Nitric Oxide Study (mortality 32, loss to follow-up 9) received loop diuretics, aminoglycosides, and neuromuscular blockers (NMB), and 50 received vancomycin as neonates. Prospective, longitudinal secondary outcome using audiological tests diagnosed late-onset, progressive SNHL in 43 (53%); not flat (sloping) in 29, flat (severe to profound) in 14. Risk for SNHL was determined. Results: A combination of duration of diuretic use of >14 d and average NMB dose of >0.96 mg/kg/d contributed to SNHL among survivors (odds ratio 5.2; 95% CI 1.6, 16.7). Markers of illness severity did not contribute. Dosage or duration of aminoglycosides use did not relate to SNHL. Cumulative dosages and duration of use of diuretics; NMB; use of vancomycin; and overlap of diuretics with NMB, aminoglycosides, and vancomycin individually linked to SNHL ( p Conclusion: Overuse of loop diuretics and/or NMB contributes to SNHL after neonatal respiratory failure; markers of illness severity or the appropriate administration of aminoglycosides do not. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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