التفاصيل البيبلوغرافية
| العنوان: |
Circulating Cell-Derived Microparticles in Crohn’s Disease. |
| المؤلفون: |
Patrick Chamouard, Dominique Desprez, Bénédicte Hugel, Corinne Kunzelmann, Carole Gidon-Jeangirard, Michel Lessard, René Baumann, Jean-Marie Freyssinet, Lélia Grunebaum |
| المصدر: |
Digestive Diseases & Sciences; Mar2005, Vol. 50 Issue 3, p574-580, 7p |
| مستخلص: |
Abstract Procoagulant membrane microparticles can be released from activated or apoptotic cells in response to various environmental stimuli. The aim of this study was to investigate the presence of microparticles in Crohn’s disease and to assess their variations after infliximab therapy. We compared the levels of circulating microparticles in 38 patients with Crohn’s disease, 16 patients with ulcerative colitis, 7 patients with infectious colitis, and 17 control subjects. The evolution of microparticle levels was assessed after infliximab therapy in 13 patients with Crohn’s disease. Circulating microparticle levels were elevated in patients with Crohn’s disease (9.31 ± 0.66 nmol/L phosphatidylserine equivalent [PS Eq]) or infectious colitis (10.71 ± 0.92 nmol/L PS Eq) compared to patients with ulcerative colitis (5.75 ± 0.59 nmol/L PS Eq) and control subjects (4.06 ± 0.37 nmol/L PS Eq) (P = 0.001). Infliximab induced a significant diminution of the amounts of circulating microparticles, from 10.33 ± 1.20 to 6.45 ± 0.90 nmol/L PS Eq (P = 0.002). Generation of circulating microparticles occurs in Crohn’s disease; infliximab induces significant diminution. Release of microparticles could be linked to the type of inflammatory response underlying Crohn’s disease. [ABSTRACT FROM AUTHOR] |
|
Copyright of Digestive Diseases & Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder