التفاصيل البيبلوغرافية
| العنوان: |
Expression of HLA-DP0401 Molecules for Identification of DP0401 Restricted Antigen Specific T Cells. |
| المؤلفون: |
Junbao Yang, Laurel Huston, Deanna Berger, Nancy A. Danke, Andrew W. Liu, Mary L. Disis, William W. Kwok |
| المصدر: |
Journal of Clinical Immunology; Sep2005, Vol. 25 Issue 5, p428-436, 9p |
| مستخلص: |
Abstract Human histocompatibility leukocyte antigen (HLA)-DPA1*0103/DPB1*0401 (DP0401) is the most common HLA class II molecule and is present in approximately 45% of the Caucasian population. In this study, soluble HLA-DP0401 molecules were expressed as “empty’’ class II molecules in insect cells. Utilizing these soluble DP molecules and the Tetramer Guided Epitope Mapping (TGEM) approach, the influenza A Puerto Rico/8/34 matrix protein (MP) derived peptide MP41−60 VLMEWLKTRPILSPLTKGIL and the Clostridium tetani Tetanus Toxin (TT) derived peptide TT634−653 DKISDVSTIVPYIGPALNIV were identified as the DP0401 restricted MP and TT epitopes, respectively. In addition, T cells specific for the cancer testis antigen NY-ESO-1 and the breast/ovarian cancer over-expressing antigen Her-2/neu were detected in DP0401 subjects by DP0401 tetramers. The availability of HLA-DP0401 tetramers should facilitate the study of DP restricted T cell responses. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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