التفاصيل البيبلوغرافية
| العنوان: |
Factors predictive of 5-year survival after transarterial chemoembolization for inoperable hepatocellular carcinoma. |
| المؤلفون: |
O'Suilleabhain, C. B., Poon, R. T. P., Yong, J. L., Ooi, G. C., Tso, W. K., Fan, S. T. |
| المصدر: |
British Journal of Surgery; Mar2003, Vol. 90 Issue 3, p325-331, 7p, 1 Diagram, 4 Charts |
| مصطلحات موضوعية: |
THERAPEUTIC embolization, LIVER cancer, ALBUMINS, TUMORS, ALPHA fetoproteins |
| مستخلص: |
Background: Transarterial chemoembolization (TACE) is widely used for unresectable hepatocellular carcinoma (HCC), but the long-term survival benefit remains unclear. Methods: Pretreatment variables were analysed for factors predictive of actual 5-year survival from a prospective database of patients with inoperable HCC treated by TACE between 1989 and 1996. Results: Complete 5-year follow-up (median 91 months) was obtained for 320 patients who underwent a median of 4 (range 1-41) TACEs. Median tumour size was 9 (range 1-28) cm. There were 25 5-year survivors (8 per cent), including eight with tumours larger than 10 cm in diameter and three with portal vein branch involvement. On univariate analysis, female gender (P = 0.037), absence of ascites (P = 0.028), platelet count below 150 x l09 per litre (P = 0.011), albumin concentration greater than 35 g/l (P = 0.04), α-fetoprotein level below 1000 ng/ml (P = 0.007), unilobar tumour (P = 0.027), fewer than three tumours (P = 0.015), absence of venous invasion (P = 0.011), and tumour diameter less than 8 cm (P = 0.021) were significant predictors of 5-year survival. Albumin concentration greater than 35 g/l (P = 0.011), unilobar tumour (P = 0.012) and α-fetoprotein level below 1000 ng/ml (P = 0.014) were independent prognostic factors on multivariate analysis. Conclusion: Five-year survival is possible with TACE for inoperable HCC, even in some patients with advanced tumours. Unilobar tumours, α-fetoprotein level below 1000 ng/ml and albumin concentration greater than 35 g/l were factors predictive of 5-year survival [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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