التفاصيل البيبلوغرافية
| العنوان: |
Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer. |
| المؤلفون: |
Maureen Murtaugh, Karen Curtin, Carol Sweeney, Roger Wolff, Richard Holubkov, Bette Caan, Martha Slattery |
| المصدر: |
Cancer Causes & Control; Mar2007, Vol. 18 Issue 2, p153-163, 11p |
| مصطلحات موضوعية: |
RECTAL cancer, GENETIC polymorphisms, METABOLISM, METHIONINE |
| مستخلص: |
Abstract??Little is known about the contribution of polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and the folate metabolism pathway in rectal cancer alone. Data were from participants in a case?control study conducted in Northern California and Utah (751 cases and 979 controls). We examined independent associations and interactions of folate, B vitamins, methionine, alcohol, andMTHFRpolymorphisms (MTHFR C677TandA1298C)with rectal cancer. Dietary folate intake was associated with a reduction in rectal cancer OR 0.66, 95% CI 0.48?0.92 (>475 mcg day compared to < = 322 mcg) as was a combination of nutrient intakes contributing to higher methyl donor status (OR 0.79, 95% CI 0.66?0.95). Risk was reduced among women with the677 TTgenotype (OR 0.54, 95% CI 0.30?0.9), but not men (OR 1.11, 95% CI 0.70?1.76) and with the1298CCgenotype in combined gender analysis (OR 0.67, 95% CI 0.46?0.98). These data are consistent with a protective effect of increasing dietary folate against rectal cancer and suggest a protective role of theMTHFR 677 TTgenotype in women and1298CC in men and women. Folate intake, low methyl donor status, andMTHFRpolymorphisms may play independent roles in the etiology of rectal cancer. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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